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Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae.

ABSTRACT: The 2,160,267 bp genome sequence of Streptococcus agalactiae, the leading cause of bacterial sepsis, pneumonia, and meningitis in neonates in the U.S. and Europe, is predicted to encode 2,175 genes. Genome comparisons among S. agalactiae, Streptococcus pneumoniae, Streptococcus pyogenes, and the other completely sequenced genomes identified genes specific to the streptococci and to S. agalactiae. These in silico analyses, combined with comparative genome hybridization experiments between the sequenced serotype V strain 2603 V/R and 19 S. agalactiae strains from several serotypes using whole-genome microarrays, revealed the genetic heterogeneity among S. agalactiae strains, even of the same serotype, and provided insights into the evolution of virulence mechanisms.

SUBMITTER: Tettelin H 

PROVIDER: S-EPMC129455 | biostudies-literature | 2002 Sep

REPOSITORIES: biostudies-literature

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Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae.

Tettelin Herve H   Masignani Vega V   Cieslewicz Michael J MJ   Eisen Jonathan A JA   Peterson Scott S   Wessels Michael R MR   Paulsen Ian T IT   Nelson Karen E KE   Margarit Immaculada I   Read Timothy D TD   Madoff Lawrence C LC   Wolf Alex M AM   Beanan Maureen J MJ   Brinkac Lauren M LM   Daugherty Sean C SC   DeBoy Robert T RT   Durkin A Scott AS   Kolonay James F JF   Madupu Ramana R   Lewis Matthew R MR   Radune Diana D   Fedorova Nadezhda B NB   Scanlan David D   Khouri Hoda H   Mulligan Stephanie S   Carty Heather A HA   Cline Robin T RT   Van Aken Susan E SE   Gill John J   Scarselli Maria M   Mora Marirosa M   Iacobini Emilia T ET   Brettoni Cecilia C   Galli Giuliano G   Mariani Massimo M   Vegni Filippo F   Maione Domenico D   Rinaudo Daniela D   Rappuoli Rino R   Telford John L JL   Kasper Dennis L DL   Grandi Guido G   Fraser Claire M CM  

Proceedings of the National Academy of Sciences of the United States of America 20020828 19

The 2,160,267 bp genome sequence of Streptococcus agalactiae, the leading cause of bacterial sepsis, pneumonia, and meningitis in neonates in the U.S. and Europe, is predicted to encode 2,175 genes. Genome comparisons among S. agalactiae, Streptococcus pneumoniae, Streptococcus pyogenes, and the other completely sequenced genomes identified genes specific to the streptococci and to S. agalactiae. These in silico analyses, combined with comparative genome hybridization experiments between the seq  ...[more]

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