B cells develop in the zebrafish pancreas.
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ABSTRACT:
SUBMITTER: Danilova N
PROVIDER: S-EPMC129751 | biostudies-literature | 2002 Oct
REPOSITORIES: biostudies-literature
Publications
B cells develop in the zebrafish pancreas.
Danilova Nadia N Steiner Lisa A LA
Proceedings of the National Academy of Sciences of the United States of America 20021007 21
The zebrafish, with its transparent free-living embryo, is a useful organism for investigating early stages in lymphopoiesis. Previously, we showed that T cells differentiate in the thymus by day 4, but no sites for B cell differentiation were seen until 3 weeks. We report here that on day 4, we detect rearrangements of genes encoding B cell receptors in DNA extracted from whole fish. Also by day 4, rag1 transcripts are seen in the pancreas, an organ not previously associated with lymphopoiesis; ...[more]
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