ChIPOTle: a user-friendly tool for the analysis of ChIP-chip data.
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ABSTRACT:
SUBMITTER: Buck MJ
PROVIDER: S-EPMC1297653 | biostudies-literature | 2005
REPOSITORIES: biostudies-literature
Publications
ChIPOTle: a user-friendly tool for the analysis of ChIP-chip data.
Buck Michael J MJ Nobel Andrew B AB Lieb Jason D JD
Genome biology 20051019 11
ChIPOTle (Chromatin ImmunoPrecipitation On Tiled arrays) takes advantage of two unique properties of ChIP-chip data: the single-tailed nature of the data, caused by specific enrichment but not specific depletion of genomic fragments; and the predictable enrichment of DNA fragments adjacent to sites of direct protein-DNA interaction. Implemented as a Microsoft Excel macro written in Visual Basic, ChIPOTle uses a sliding window approach that yields improvements in the identification of bona fide s ...[more]
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