Ontology highlight
ABSTRACT:
SUBMITTER: Koch MA
PROVIDER: S-EPMC1297657 | biostudies-literature | 2005 Nov
REPOSITORIES: biostudies-literature
Koch Marcus A MA Schuffenhauer Ansgar A Scheck Michael M Wetzel Stefan S Casaulta Marco M Odermatt Alex A Ertl Peter P Waldmann Herbert H
Proceedings of the National Academy of Sciences of the United States of America 20051121 48
The identification of small molecules that fall within the biologically relevant subfraction of vast chemical space is of utmost importance to chemical biology and medicinal chemistry research. The prerequirement of biological relevance to be met by such molecules is fulfilled by natural product-derived compound collections. We report a structural classification of natural products (SCONP) as organizing principle for charting the known chemical space explored by nature. SCONP arranges the scaffo ...[more]