Ontology highlight
ABSTRACT:
SUBMITTER: Coombes BK
PROVIDER: S-EPMC1297660 | biostudies-literature | 2005 Nov
REPOSITORIES: biostudies-literature
Coombes Brian K BK Wickham Mark E ME Lowden Michael J MJ Brown Nat F NF Finlay B Brett BB
Proceedings of the National Academy of Sciences of the United States of America 20051121 48
Salmonella enterica relies on a type III secretion system encoded in Salmonella pathogenicity island-2 (SPI-2) to survive and replicate within macrophages at systemic sites during typhoid. SPI-2 virulence is induced upon entry into macrophages, but the mechanisms of SPI-2 gene control in vivo remain unclear, particularly with regard to negative regulators that control the contextual activation of SPI-2. Here, we identified and characterized YdgT as a negative modulator of the SPI-2 pathogenicity ...[more]