Ontology highlight
ABSTRACT:
SUBMITTER: Hwang D
PROVIDER: S-EPMC1297682 | biostudies-literature | 2005 Nov
REPOSITORIES: biostudies-literature
Hwang Daehee D Rust Alistair G AG Ramsey Stephen S Smith Jennifer J JJ Leslie Deena M DM Weston Andrea D AD de Atauri Pedro P Aitchison John D JD Hood Leroy L Siegel Andrew F AF Bolouri Hamid H
Proceedings of the National Academy of Sciences of the United States of America 20051121 48
Different experimental technologies measure different aspects of a system and to differing depth and breadth. High-throughput assays have inherently high false-positive and false-negative rates. Moreover, each technology includes systematic biases of a different nature. These differences make network reconstruction from multiple data sets difficult and error-prone. Additionally, because of the rapid rate of progress in biotechnology, there is usually no curated exemplar data set from which one m ...[more]