Ontology highlight
ABSTRACT:
SUBMITTER: Loewer A
PROVIDER: S-EPMC1299033 | biostudies-literature | 2004 Apr
REPOSITORIES: biostudies-literature
Loewer Alexander A Soba Peter P Beyreuther Konrad K Paro Renato R Merdes Gunter G
EMBO reports 20040401 4
The cleavage of proteins within their transmembrane domain by Presenilin (PS) has an important role in different signalling pathways and in Alzheimer's disease. Nevertheless, not much is known about the regulation of PS activity. It has been suggested that substrate recognition by the PS complex depends only on the size of the extracellular domain independent of the amino-acid sequence and that PS activity is constitutive in all cells that express the minimal components of the complex. We report ...[more]