Ontology highlight
ABSTRACT:
SUBMITTER: Boutonnet C
PROVIDER: S-EPMC1299091 | biostudies-literature | 2004 Jul
REPOSITORIES: biostudies-literature
Boutonnet Christel C Boijoux Olivier O Bernat Sandra S Kharrat Abdelhakkim A Favre Gilles G Faye Jean-Charles JC Vagner Stéphan S
EMBO reports 20040611 7
In the quest for the development of pharmacological switches that control gene expression, no system has been reported that regulates at the translational level. To permit small-molecule control of transgene translation, we have constructed a farnesyl transferase inhibitor-responsive translation initiation factor. This artificial protein is a three-component chimaera consisting of the ribosome recruitment core of the eIF4G1 eukaryotic translation initiation factor, the RNA-binding domain of the ...[more]