Ontology highlight
ABSTRACT:
SUBMITTER: Court R
PROVIDER: S-EPMC1299224 | biostudies-literature | 2005 Jan
REPOSITORIES: biostudies-literature
Court Robert R Chapman Lynda L Fairall Louise L Rhodes Daniela D
EMBO reports 20050101 1
Human telomeres consist of tandem arrays of TTAGGG sequence repeats that are specifically bound by two proteins, TRF1 and TRF2. They bind to DNA as preformed homodimers and have the same architecture in which the DNA-binding domains (Dbds) form independent structural units. Despite these similarities, TRF1 and TRF2 have different functions at telomeres. The X-ray crystal structures of both TRF1- and TRF2-Dbds in complex with telomeric DNA (2.0 and 1.8 angstroms resolution, respectively) show tha ...[more]