Ontology highlight
ABSTRACT:
SUBMITTER: Kuper J
PROVIDER: S-EPMC1299240 | biostudies-literature | 2005 Feb
REPOSITORIES: biostudies-literature
Kuper Jochen J Doenges Catharina C Wilmanns Matthias M
EMBO reports 20050201 2
Some bacterial genomes contain an incomplete set of genes encoding phosphoribosyl isomerases, raising the question of whether there exists broadened substrate specificity for the missing gene products. To investigate the underlying molecular principles of this hypothesis, we have determined the crystal structure of the bifunctional enzyme PriA from Streptomyces coelicolor at 1.8 A resolution. It consists of a (betaalpha)(8)-barrel fold that is assembled by two symmetric (betaalpha)(4) half-barre ...[more]