Ontology highlight
ABSTRACT:
SUBMITTER: Agaphonov MO
PROVIDER: S-EPMC130179 | biostudies-literature | 2002 Oct
REPOSITORIES: biostudies-literature
Agaphonov Michael O MO Romanova Nina V NV Trushkina Polina M PM Smirnov Vladimir N VN Ter-Avanesyan Michael D MD
BMC molecular biology 20021007
<h4>Background</h4>Secretion of recombinant proteins in yeast can be affected by their improper folding in the endoplasmic reticulum and subsequent elimination of the misfolded molecules via the endoplasmic reticulum associated protein degradation pathway. Recombinant proteins can also be degraded by the vacuolar protease complex. Human urokinase type plasminogen activator (uPA) is poorly secreted by yeast but the mechanisms interfering with its secretion are largely unknown.<h4>Results</h4>We s ...[more]