Freezing of a fish antifreeze protein results in amyloid fibril formation.
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ABSTRACT:
SUBMITTER: Graether SP
PROVIDER: S-EPMC1302635 | biostudies-literature | 2003 Jan
REPOSITORIES: biostudies-literature
Publications
Freezing of a fish antifreeze protein results in amyloid fibril formation.
Graether Steffen P SP Slupsky Carolyn M CM Sykes Brian D BD
Biophysical journal 20030101 1
Amyloid is associated with a number of diseases including Alzheimer's, Huntington's, Parkinson's, and the spongiform encephalopathies. Amyloid fibrils have been formed in vitro from both disease and nondisease related proteins, but the latter requires extremes of pH, heat, or the presence of a chaotropic agent. We show, using fluorescence spectroscopy, electron microscopy, and solid-state NMR spectroscopy, that the alpha-helical type I antifreeze protein from the winter flounder forms amyloid fi ...[more]
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