Nanotubules formed by highly hydrophobic amphiphilic alpha-helical peptides and natural phospholipids.

ABSTRACT: We previously reported that the 18-mer amphiphilic alpha-helical peptide, Hel 13-5, consisting of 13 hydrophobic residues and five hydrophilic amino acid residues, can induce neutral liposomes (egg yolk phosphatidylcholine) to adopt long nanotubular structures and that the interaction of specific peptides with specific phospholipid mixtures induces the formation of membrane structures resembling cellular organelles such as the Golgi apparatus. In the present study we focused our attention on the effects of peptide sequence and chain length on the nanotubule formation occurring in mixture systems of Hel 13-5 and various neutral and acidic lipid species by means of turbidity measurements, dynamic light scattering measurements, and electron microscopy. We designed and synthesized two sets of

SUBMITTER: Furuya T 

PROVIDER: S-EPMC1302764 | biostudies-literature | 2003 Mar

REPOSITORIES: biostudies-literature