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ABSTRACT:
SUBMITTER: Humpherys D
PROVIDER: S-EPMC130555 | biostudies-literature | 2002 Oct
REPOSITORIES: biostudies-literature
Humpherys David D Eggan Kevin K Akutsu Hidenori H Friedman Adam A Hochedlinger Konrad K Yanagimachi Ryuzo R Lander Eric S ES Golub Todd R TR Jaenisch Rudolf R
Proceedings of the National Academy of Sciences of the United States of America 20020916 20
To assess the extent of abnormal gene expression in clones, we assessed global gene expression by microarray analysis on RNA from the placentas and livers of neonatal cloned mice derived by nuclear transfer (NT) from both cultured embryonic stem cells and freshly isolated cumulus cells. Direct comparison of gene expression profiles of more than 10,000 genes showed that for both donor cell types approximately 4% of the expressed genes in the NT placentas differed dramatically in expression levels ...[more]