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The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts.


ABSTRACT: The 3.31-Mb genome sequence of the intracellular pathogen and potential bioterrorism agent, Brucella suis, was determined. Comparison of B. suis with Brucella melitensis has defined a finite set of differences that could be responsible for the differences in virulence and host preference between these organisms, and indicates that phage have played a significant role in their divergence. Analysis of the B. suis genome reveals transport and metabolic capabilities akin to soil/plant-associated bacteria. Extensive gene synteny between B. suis chromosome 1 and the genome of the plant symbiont Mesorhizobium loti emphasizes the similarity between this animal pathogen and plant pathogens and symbionts. A limited repertoire of genes homologous to known bacterial virulence factors were identified.

SUBMITTER: Paulsen IT 

PROVIDER: S-EPMC130601 | biostudies-literature | 2002 Oct

REPOSITORIES: biostudies-literature

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The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts.

Paulsen Ian T IT   Seshadri Rekha R   Nelson Karen E KE   Eisen Jonathan A JA   Heidelberg John F JF   Read Timothy D TD   Dodson Robert J RJ   Umayam Lowell L   Brinkac Lauren M LM   Beanan Maureen J MJ   Daugherty Sean C SC   Deboy Robert T RT   Durkin A Scott AS   Kolonay James F JF   Madupu Ramana R   Nelson William C WC   Ayodeji Bola B   Kraul Margaret M   Shetty Jyoti J   Malek Joel J   Van Aken Susan E SE   Riedmuller Steven S   Tettelin Herve H   Gill Steven R SR   White Owen O   Salzberg Steven L SL   Hoover David L DL   Lindler Luther E LE   Halling Shirley M SM   Boyle Stephen M SM   Fraser Claire M CM  

Proceedings of the National Academy of Sciences of the United States of America 20020923 20


The 3.31-Mb genome sequence of the intracellular pathogen and potential bioterrorism agent, Brucella suis, was determined. Comparison of B. suis with Brucella melitensis has defined a finite set of differences that could be responsible for the differences in virulence and host preference between these organisms, and indicates that phage have played a significant role in their divergence. Analysis of the B. suis genome reveals transport and metabolic capabilities akin to soil/plant-associated bac  ...[more]

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