Ontology highlight
ABSTRACT:
SUBMITTER: Martinez SE
PROVIDER: S-EPMC130621 | biostudies-literature | 2002 Oct
REPOSITORIES: biostudies-literature
Martinez Sergio E SE Wu Albert Y AY Glavas Natalie A NA Tang Xiao-Bo XB Turley Stewart S Hol Wim G J WG Beavo Joseph A JA
Proceedings of the National Academy of Sciences of the United States of America 20020923 20
Cyclic nucleotide phosphodiesterases (PDEs) regulate all pathways that use cGMP or cAMP as a second messenger. Five of the 11 PDE families have regulatory segments containing GAF domains, 3 of which are known to bind cGMP. In PDE2 binding of cGMP to the GAF domain causes an activation of the catalytic activity by a mechanism that apparently is shared even in the adenylyl cyclase of Anabaena, an organism separated from mouse by 2 billion years of evolution. The 2.9-A crystal structure of the mous ...[more]