Ontology highlight
ABSTRACT:
SUBMITTER: Shin J
PROVIDER: S-EPMC1306792 | biostudies-literature | 2005 Dec
REPOSITORIES: biostudies-literature
Shin Jonghan J Kim Daesoo D Bianchi Riccardo R Wong Robert K S RK Shin Hee-Sup HS
Proceedings of the National Academy of Sciences of the United States of America 20051205 50
Rhythmic oscillatory activities at the theta frequency (4-12 Hz) in the hippocampus have long-attracted attention because they have been implicated in diverse brain functions, including spatial cognition. Although studies based on pharmacology and lesion experiments suggested heterogeneity of these rhythms and their behavioral correlates, controversies are abundant on these issues. Here we show that mice harboring a phospholipase C (PLC)-beta1(-/-) mutation (PLC-beta1(-/-) mice) lack one subset ...[more]