Direct detection of Helicobacter pylori mutations associated with macrolide resistance in gastric biopsy material taken from human immunodeficiency virus-infected subjects.
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ABSTRACT:
SUBMITTER: Scarpellini P
PROVIDER: S-EPMC130724 | biostudies-literature | 2002 Jun
REPOSITORIES: biostudies-literature
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Direct detection of Helicobacter pylori mutations associated with macrolide resistance in gastric biopsy material taken from human immunodeficiency virus-infected subjects.
Scarpellini Paolo P Carrera Paola P Cavallero Annalisa A Cernuschi Massimo M Mezzi Gianni G Testoni Pier Alberto PA Zingale Anna A Lazzarin Adriano A
Journal of clinical microbiology 20020601 6
One hundred forty gastric biopsies were tested by microbiological methods and by amplifying a sequence of 23S rRNA and identifying mutations associated to clarithromycin resistance. Seventy-six specimens were positive for Helicobacter pylori. Mutational analysis revealed alterations in 18 (39.1%) of 46 and 2 (8.7%) of 23 samples from human immunodeficiency virus-seropositive and -seronegative persons, respectively. The results of the mutational analysis fully correlated with those of the suscept ...[more]
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