Ontology highlight
ABSTRACT:
SUBMITTER: Verrecchia F
PROVIDER: S-EPMC1307596 | biostudies-literature | 2002 Nov
REPOSITORIES: biostudies-literature
Verrecchia Franck F Wagner Erwin F EF Mauviel Alain A
EMBO reports 20021022 11
We used a gene knockout approach to elucidate the specific roles played by the Jun-N-terminal kinase (JNK) and NF-kappaB pathways downstream of TNF-alpha in the context of alpha(2) type I collagen gene (COL1A2) expression. In JNK1-/--JNK2-/- (JNK-/-) fibroblasts, TNF-alpha inhibited basal COL1A2 expression but had no effect on TGF-beta-driven gene transactivation unless jnk1 was introduced ectopically. Conversely, in NF-kappaB essential modulator-/- (NEMO-/-) fibroblasts, lack of NF-kappaB activ ...[more]