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PVF2, a PDGF/VEGF-like growth factor, induces hemocyte proliferation in Drosophila larvae.

ABSTRACT: Blood cells play a crucial role in both morphogenetic and immunological processes in Drosophila, yet the factors regulating their proliferation remain largely unknown. In order to address this question, we raised antibodies against a tumorous blood cell line and identified an antigenic determinant that marks the surface of prohemocytes and also circulating plasmatocytes in larvae. This antigen was identified as a Drosophila homolog of the mammalian receptor for platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF). The Drosophila receptor controls cell proliferation in vitro. By overexpressing in vivo one of its putative ligands, PVF2, we induced a dramatic increase in circulating hemocytes. These results identify the PDGF/VEGF receptor homolog and one of its ligands as important players in Drosophila hematopoiesis.

SUBMITTER: Munier AI

PROVIDER: S-EPMC1308320 | biostudies-literature | 2002 Dec

REPOSITORIES: biostudies-literature

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PVF2, a PDGF/VEGF-like growth factor, induces hemocyte proliferation in Drosophila larvae.

Munier Anne-Isabelle AI Doucet Daniel D Perrodou Emmanuel E Zachary Daniel D Meister Marie M Hoffmann Jules A JA Janeway Charles A CA Lagueux Marie M

EMBO reports 20021121 12

Blood cells play a crucial role in both morphogenetic and immunological processes in Drosophila, yet the factors regulating their proliferation remain largely unknown. In order to address this question, we raised antibodies against a tumorous blood cell line and identified an antigenic determinant that marks the surface of prohemocytes and also circulating plasmatocytes in larvae. This antigen was identified as a Drosophila homolog of the mammalian receptor for platelet-derived growth factor (PD ...[more]

PMID: 12446570

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