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High prevalence of cagA- and babA2-positive Helicobacter pylori clinical isolates in Taiwan.

ABSTRACT: Two virulence markers, cagA and babA2, were characterized by PCR in 101 Helicobacter pylori isolates from a population in Taiwan. cagA was detected in 99% of the isolates, while babA2 was present in all of the isolates. Base deletions and substitutions at the forward babA2 primer annealing sites were found. Given their high prevalence, cagA and babA2 cannot be useful markers for predicting the high-risk patients of H. pylori infection in Taiwan.

SUBMITTER: Lai CH

PROVIDER: S-EPMC130881 | biostudies-literature | 2002 Oct

REPOSITORIES: biostudies-literature

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High prevalence of cagA- and babA2-positive Helicobacter pylori clinical isolates in Taiwan.

Lai Chih-Ho CH Kuo Chun-Hsien CH Chen Ya-Chi YC Chao Fang-Yu FY Poon Sek-Kwong SK Chang Chi-Sen CS Wang Wen-Ching WC

Journal of clinical microbiology 20021001 10

Two virulence markers, cagA and babA2, were characterized by PCR in 101 Helicobacter pylori isolates from a population in Taiwan. cagA was detected in 99% of the isolates, while babA2 was present in all of the isolates. Base deletions and substitutions at the forward babA2 primer annealing sites were found. Given their high prevalence, cagA and babA2 cannot be useful markers for predicting the high-risk patients of H. pylori infection in Taiwan. ...[more]

PMID: 12354901

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