Ontology highlight
ABSTRACT:
SUBMITTER: Chen JG
PROVIDER: S-EPMC1308928 | biostudies-literature | 2005 Dec
REPOSITORIES: biostudies-literature
Chen Jie-Guang JG Rasin Mladen-Roko MR Kwan Kenneth Y KY Sestan Nenad N
Proceedings of the National Academy of Sciences of the United States of America 20051128 49
Pyramidal neurons of the cerebral cortex display marked layer- and subtype-specific differences in their axonal projections and dendritic morphologies. Here we show that transcription factor Zfp312 is selectively expressed by layer V and VI subcortical projection pyramidal neurons and their progenitor cells. Knocking down Zfp312 with small interfering RNAs dramatically reduced the number of subcortical axonal projections from deep-layer pyramidal neurons and altered their dendritic morphology. I ...[more]