Attenuation of the activity of caspofungin at high concentrations against candida albicans: possible role of cell wall integrity and calcineurin pathways.
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ABSTRACT:
SUBMITTER: Wiederhold NP
PROVIDER: S-EPMC1315970 | biostudies-literature | 2005 Dec
REPOSITORIES: biostudies-literature
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Attenuation of the activity of caspofungin at high concentrations against candida albicans: possible role of cell wall integrity and calcineurin pathways.
Wiederhold Nathan P NP Kontoyiannis Dimitrios P DP Prince Randall A RA Lewis Russell E RE
Antimicrobial agents and chemotherapy 20051201 12
Caspofungin had diminished activity in vitro against Candida albicans at concentrations of 8 to 32 microg/ml. This phenomenon was markedly attenuated in a deltamkc1/deltamkc1 deletion mutant and by the addition of cyclosporine to the wild type. Short exposure to these caspofungin concentrations resulted in MKC1 up-regulation, suggesting roles of cell wall integrity and calcineurin pathways. ...[more]
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