Ontology highlight
ABSTRACT:
SUBMITTER: Wiederhold NP
PROVIDER: S-EPMC1315970 | biostudies-literature | 2005 Dec
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20051201 12
Caspofungin had diminished activity in vitro against Candida albicans at concentrations of 8 to 32 microg/ml. This phenomenon was markedly attenuated in a deltamkc1/deltamkc1 deletion mutant and by the addition of cyclosporine to the wild type. Short exposure to these caspofungin concentrations resulted in MKC1 up-regulation, suggesting roles of cell wall integrity and calcineurin pathways. ...[more]