The pseudorabies virus VP1/2 tegument protein is required for intracellular capsid transport.
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ABSTRACT:
SUBMITTER: Luxton GW
PROVIDER: S-EPMC1317523 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
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The pseudorabies virus VP1/2 tegument protein is required for intracellular capsid transport.
Luxton G W Gant GW Lee Joy I-Hsuan JI Haverlock-Moyns Sarah S Schober Joseph Martin JM Smith Gregory Allan GA
Journal of virology 20060101 1
Transport of capsids in cells is critical to alphaherpesvirus infection and pathogenesis; however, viral factors required for transport have yet to be identified. Here we provide a detailed examination of capsid dynamics during the egress phase of infection in Vero cells infected with pseudorabies virus. We demonstrate that the VP1/2 tegument protein is required for processive microtubule-based transport of capsids in the cytoplasm. A second tegument protein that binds to VP1/2, UL37, was necess ...[more]
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