Ontology highlight
ABSTRACT:
SUBMITTER: Gouda H
PROVIDER: S-EPMC1317948 | biostudies-literature | 2005 Dec
REPOSITORIES: biostudies-literature
Gouda Hiroaki H Sunazuka Toshiaki T Ui Hideaki H Handa Masaki M Sakoh Yusuke Y Iwai Yuzuru Y Hirono Shuichi S Omura Satoshi S
Proceedings of the National Academy of Sciences of the United States of America 20051212 51
The absolute stereostructure of luminamicin, an anaerobic antibiotic, has been determined by using conformational analysis via high-temperature molecular dynamics, NMR spectroscopy, and the modified Mosher method. It was found that luminamicin has the S, S, R, R, R, R, S, S, S, R, and S configurations at C2, C4, C7, C9, C10, C11, C12, C13, C16, C28, and C29, respectively. This configuration is the same as that found in nodusmicin, which has a chemical structure quite similar to luminamicin. The ...[more]