Ontology highlight
ABSTRACT:
SUBMITTER: Taylor SC
PROVIDER: S-EPMC1319153 | biostudies-literature | 2003 Apr
REPOSITORIES: biostudies-literature
Taylor Sean C SC Thibault Pierre P Tessier Daniel C DC Bergeron John J M JJ Thomas David Y DY
EMBO reports 20030401 4
Secretory and membrane N-linked glycoproteins undergo folding and oligomeric assembly in the endoplasmic reticulum with the aid of a folding mechanism known as the calnexin cycle. UDP-glucose glycoprotein:glucosyltransferase (UGGT) is the sensor component of the calnexin cycle, which recognizes these glycoproteins when they are incompletely folded, and transfers a glucose residue from UDP-glucose to N-linked Man9-GlcNAc2 glycans. To determine how UGGT recognizes incompletely folded glycoproteins ...[more]