Ontology highlight
ABSTRACT:
SUBMITTER: Grenklo S
PROVIDER: S-EPMC1319178 | biostudies-literature | 2003 May
REPOSITORIES: biostudies-literature
EMBO reports 20030501 5
We have examined the effect of covalently crosslinked profilin-actin (PxA), which closely matches the biochemical properties of ordinary profilin-actin and interferes with actin polymerization in vitro and in vivo, on Listeria monocytogenes motility. PxA caused a marked reduction in bacterial motility, which was accompanied by the detachment of bacterial tails. The effect of PxA was dependent on its binding to proline-rich sequences, as shown by the inability of PH133SxA, which cannot interact w ...[more]