Ontology highlight
ABSTRACT:
SUBMITTER: He H
PROVIDER: S-EPMC1323209 | biostudies-literature | 2005 Dec
REPOSITORIES: biostudies-literature
He Huiling H Jazdzewski Krystian K Li Wei W Liyanarachchi Sandya S Nagy Rebecca R Volinia Stefano S Calin George A GA Liu Chang-Gong CG Franssila Kaarle K Suster Saul S Kloos Richard T RT Croce Carlo M CM de la Chapelle Albert A
Proceedings of the National Academy of Sciences of the United States of America 20051219 52
Apart from alterations in the RET/PTC-RAS-BRAF pathway, comparatively little is known about the genetics of papillary thyroid carcinoma (PTC). We show that numerous microRNAs (miRNAs) are transcriptionally up-regulated in PTC tumors compared with unaffected thyroid tissue. A set of five miRNAs, including the three most up-regulated ones (miR-221, -222, and -146), distinguished unequivocally between PTC and normal thyroid. Additionally, miR-221 was up-regulated in unaffected thyroid tissue in sev ...[more]