Ontology highlight
ABSTRACT:
SUBMITTER: Shiina H
PROVIDER: S-EPMC1324980 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Shiina Hiroko H Matsumoto Takahiro T Sato Takashi T Igarashi Katsuhide K Miyamoto Junko J Takemasa Sayuri S Sakari Matomo M Takada Ichiro I Nakamura Takashi T Metzger Daniel D Chambon Pierre P Kanno Jun J Yoshikawa Hiroyuki H Kato Shigeaki S
Proceedings of the National Academy of Sciences of the United States of America 20051222 1
Premature ovarian failure (POF) syndrome, an early decline of ovarian function in women, is frequently associated with X chromosome abnormalities ranging from various Xq deletions to complete loss of one of the X chromosomes. However, the genetic locus responsible for the POF remains unknown, and no candidate gene has been identified. Using the Cre/LoxP system, we have disrupted the mouse X chromosome androgen receptor (Ar) gene. Female AR(-/-) mice appeared normal but developed the POF phenotyp ...[more]