Ontology highlight
ABSTRACT:
SUBMITTER: Navarro-Sanchez E
PROVIDER: S-EPMC1326316 | biostudies-literature | 2003 Jul
REPOSITORIES: biostudies-literature
EMBO reports 20030701 7
Dengue virus (DV) is a mosquito-borne flavivirus that causes haemorrhagic fever in humans. DV primarily targets immature dendritic cells (DCs) after a bite by an infected mosquito vector. Here, we analysed the interactions between DV and human-monocyte-derived DCs at the level of virus entry. We show that the DC-specific ICAM3-grabbing non-integrin (DC-SIGN) molecule, a cell-surface, mannose-specific, C-type lectin, binds mosquito-cell-derived DVs and allows viral replication. Conclusive evidenc ...[more]