Ontology highlight
ABSTRACT:
SUBMITTER: Caron C
PROVIDER: S-EPMC1326355 | biostudies-literature | 2003 Sep
REPOSITORIES: biostudies-literature
Caron Cécile C Pivot-Pajot Christophe C van Grunsven Leo A LA Col Edwige E Lestrat Cécile C Rousseaux Sophie S Khochbin Saadi S
EMBO reports 20030808 9
Cdyl (chromodomain-Y-like) is a chromodomain-containing protein that is predominantly expressed during mouse spermiogenesis. In its carboxy-terminal portion, there is a domain with homology to the coenzyme A (CoA) pocket of the enoyl-CoA hydratase/isomerase, which is shown here to be able to bind CoA and histone deacetylases (HDACs). It also efficiently represses transcription. Moreover, the binding of Hdac1 represses the ability of Cdyl to bind CoA, and a Cdyl-CoA interaction only occurs in the ...[more]