Ontology highlight
ABSTRACT:
SUBMITTER: Campbell JD
PROVIDER: S-EPMC1326373 | biostudies-literature | 2003 Nov
REPOSITORIES: biostudies-literature
Campbell Jeff D JD Sansom Mark S P MS Ashcroft Frances M FM
EMBO reports 20031101 11
The sulphonylurea receptor (SUR) is a member of the ATP-binding cassette (ABC) family of membrane proteins. It functions as the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which comprises SUR and Kir6.x proteins. Here, we review data demonstrating functional differences between the two nucleotide binding domains (NBDs) of SUR1. In addition, to explain the structural basis of these functional differences, we have constructed a molecular model of the NBD dimer of human SUR1. ...[more]