Ontology highlight
ABSTRACT:
SUBMITTER: Rosa-Calatrava M
PROVIDER: S-EPMC1326401 | biostudies-literature | 2003 Oct
REPOSITORIES: biostudies-literature
Rosa-Calatrava Manuel M Puvion-Dutilleul Francine F Lutz Pierre P Dreyer Dominique D de Thé Hugues H Chatton Bruno B Kedinger Claude C
EMBO reports 20031001 10
The product of adenovirus type 5 (Ad5) gene IX, protein IX (pIX), is a multifunctional protein that stabilizes the viral capsid and has transcriptional activity. We show that pIX also contributes to the Ad5-induced reorganization of the host-cell nuclear ultrastructure: pIX induces the formation of specific and dynamic nuclear inclusions, and the host promyelocytic leukaemia (PML) protein, which is the main structural organizer of PML bodies, is stably relocated and confined within the pIX-induc ...[more]