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AcrAB Efflux System: Expression and Contribution to Fluoroquinolone Resistance in Klebsiella spp.

ABSTRACT: Seven Klebsiella pneumoniae and four Klebsiella oxytoca clinical isolates with different levels of resistance to ciprofloxacin were studied. Mutations in the topoisomerase genes were found in almost all strains, but the contribution of a multidrug efflux system homologous to AcrAB in Escherichia coli was also observed. Overexpression of this efflux system was demonstrated by immunoblotting with antibodies against E. coli AcrA.

SUBMITTER: Mazzariol A

PROVIDER: S-EPMC132751 | biostudies-literature | 2002 Dec

REPOSITORIES: biostudies-literature

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AcrAB Efflux System: Expression and Contribution to Fluoroquinolone Resistance in Klebsiella spp.

Mazzariol Annarita A Zuliani Jessica J Cornaglia Giuseppe G Rossolini Gian Maria GM Fontana Roberta R

Antimicrobial agents and chemotherapy 20021201 12

Seven Klebsiella pneumoniae and four Klebsiella oxytoca clinical isolates with different levels of resistance to ciprofloxacin were studied. Mutations in the topoisomerase genes were found in almost all strains, but the contribution of a multidrug efflux system homologous to AcrAB in Escherichia coli was also observed. Overexpression of this efflux system was demonstrated by immunoblotting with antibodies against E. coli AcrA. ...[more]

PMID: 12435706

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Fluoroquinolone Resistance in Clinical Isolates of Klebsiella Pneumonia e.

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Campylobacter spp. prevalence and fluoroquinolone resistance in chicken layer farms.

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