Ontology highlight
ABSTRACT:
SUBMITTER: Angrisano T
PROVIDER: S-EPMC1331987 | biostudies-literature | 2006
REPOSITORIES: biostudies-literature
Angrisano Tiziana T Lembo Francesca F Pero Raffaela R Natale Francesco F Fusco Alfredo A Avvedimento Vittorio E VE Bruni Carmelo B CB Chiariotti Lorenzo L
Nucleic acids research 20060112 1
We have recently reported that a novel MBD2 interactor (MBDin) has the capacity to reactivate transcription from MBD2-repressed methylated promoters even in the absence of demethylation events. Here we show that another unrelated protein, TACC3, displays a similar activity on methylated genes. In addition the data reported here provide possible molecular mechanisms for the observed phenomenon. Immunoprecipitation experiments showed that MBD2/TACC3 form a complex in vivo with the histone acetyltr ...[more]