Ontology highlight
ABSTRACT:
SUBMITTER: Swaminathan CP
PROVIDER: S-EPMC1334652 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Swaminathan Chittoor P CP Brown Patrick H PH Roychowdhury Abhijit A Wang Qian Q Guan Rongjin R Silverman Neal N Goldman William E WE Boons Geert-Jan GJ Mariuzza Roy A RA
Proceedings of the National Academy of Sciences of the United States of America 20060109 3
The innate immune system constitutes the first line of defense against microorganisms in both vertebrates and invertebrates. Although much progress has been made toward identifying key receptors and understanding their role in host defense, far less is known about how these receptors recognize microbial ligands. Such studies have been severely hampered by the need to purify ligands from microbial sources and a reliance on biological assays, rather than direct binding, to monitor recognition. We ...[more]