Ontology highlight
ABSTRACT:
SUBMITTER: Kalkhoven E
PROVIDER: S-EPMC133676 | biostudies-literature | 2002 Apr
REPOSITORIES: biostudies-literature
Kalkhoven Eric E Teunissen Hans H Houweling Ada A Verrijzer C Peter CP Zantema Alt A
Molecular and cellular biology 20020401 7
Histone acetyltransferases (HATs) such as CBP and p300 are regarded as key regulators of RNA polymerase II-mediated transcription, but the critical structural features of their HAT modules remain ill defined. The HAT domains of CBP and p300 are characterized by the presence of a highly conserved putative plant homeodomain (PHD) (C4HC3) type zinc finger, which is part of the functionally uncharacterized cysteine-histidine-rich region 2 (CH2). Here we show that this region conforms to the PHD type ...[more]