Ontology highlight
ABSTRACT:
SUBMITTER: Biniszkiewicz D
PROVIDER: S-EPMC133685 | biostudies-literature | 2002 Apr
REPOSITORIES: biostudies-literature
Biniszkiewicz Detlev D Gribnau Joost J Ramsahoye Bernard B Gaudet François F Eggan Kevin K Humpherys David D Mastrangelo Mary-Ann MA Jun Zhan Z Walter Jörn J Jaenisch Rudolf R
Molecular and cellular biology 20020401 7
Biallelic expression of Igf2 is frequently seen in cancers because Igf2 functions as a survival factor. In many tumors the activation of Igf2 expression has been correlated with de novo methylation of the imprinted region. We have compared the intrinsic susceptibilities of the imprinted region of Igf2 and H19, other imprinted genes, bulk genomic DNA, and repetitive retroviral sequences to Dnmt1 overexpression. At low Dnmt1 methyltransferase levels repetitive retroviral elements were methylated a ...[more]