Ontology highlight
ABSTRACT:
SUBMITTER: Nakagawa T
PROVIDER: S-EPMC133713 | biostudies-literature | 2002 Apr
REPOSITORIES: biostudies-literature
Nakagawa Takahito T Takahashi Masato M Ozaki Toshinori T Watanabe Ki Ken-ichi K Todo Satoru S Mizuguchi Hiroyuki H Hayakawa Takao T Nakagawara Akira A
Molecular and cellular biology 20020401 8
p73 is a p53-related tumor suppressor but is also induced by oncogene products such as E2F-1, raising a question as to whether p73 is a tumor suppressor gene or oncogene. Unlike p53, p73 has several variants, including Delta Np73, which lacks the NH(2)-terminal transactivation domain. Although, in developing neurons, Delta Np73 is expressed abundantly and seems to inhibit the proapoptotic function of p53, the role of p73 and Delta Np73 and their regulatory mechanism in cell growth and differenti ...[more]