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A testicular germ cell-associated serine-threonine kinase, MAK, is dispensable for sperm formation.

ABSTRACT: A member of the mitogen-activated protein kinase superfamily, MAK, has been proposed to have an important role in spermatogenesis, since Mak gene expression is highly restricted to testicular germ cells. To assess the biological function of MAK, we have established MAK-deficient (Mak(-/-)) mice. Mak(-/-) mice developed normally, and no gross abnormalities were observed. Spermatogenesis of the Mak(-/-) mice was also intact, and most of the mice were fertile. However, Mak(-/-) male-derived litter sizes and their sperm motility in vitro were mildly reduced. These data show that function of MAK is not essential for spermatogenesis and male fertility.

SUBMITTER: Shinkai Y

PROVIDER: S-EPMC133803 | biostudies-literature | 2002 May

REPOSITORIES: biostudies-literature

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A testicular germ cell-associated serine-threonine kinase, MAK, is dispensable for sperm formation.

Shinkai Yoichi Y Satoh Hideo H Takeda Naoki N Fukuda Mikiko M Chiba Emiko E Kato Tomoya T Kuramochi Takashi T Araki Yoshihiko Y

Molecular and cellular biology 20020501 10

A member of the mitogen-activated protein kinase superfamily, MAK, has been proposed to have an important role in spermatogenesis, since Mak gene expression is highly restricted to testicular germ cells. To assess the biological function of MAK, we have established MAK-deficient (Mak(-/-)) mice. Mak(-/-) mice developed normally, and no gross abnormalities were observed. Spermatogenesis of the Mak(-/-) mice was also intact, and most of the mice were fertile. However, Mak(-/-) male-derived litter ...[more]

PMID: 11971961

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