Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC133809 | biostudies-literature | 2002 Jun
REPOSITORIES: biostudies-literature
Li Xinghai X Scuderi Anne A Letsou Anthea A Virshup David M DM
Molecular and cellular biology 20020601 11
Protein phosphorylation and specific protein kinases can initiate signal transduction pathways leading to programmed cell death. The specific protein phosphatases regulating apoptosis have been more elusive. Using double-stranded RNA-mediated interference (RNAi), the role of protein phosphatase 2A (PP2A) in cellular signaling was investigated. Knockdown of A or C subunits individually or of combined B subunits led to concurrent loss of nontargeted PP2A subunits, suggesting that PP2A is an obliga ...[more]