VraSR two-component regulatory system and its role in induction of pbp2 and vraSR expression by cell wall antimicrobials in Staphylococcus aureus.
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ABSTRACT:
SUBMITTER: Yin S
PROVIDER: S-EPMC1346790 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
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VraSR two-component regulatory system and its role in induction of pbp2 and vraSR expression by cell wall antimicrobials in Staphylococcus aureus.
Yin Shaohui S Daum Robert S RS Boyle-Vavra Susan S
Antimicrobial agents and chemotherapy 20060101 1
The VraS/VraR two-component system (VraSR) regulates transcriptional induction of penicillin-binding protein 2 (encoded by pbp2) by vancomycin in Staphylococcus aureus. We have now defined the vraSR operon and determined that its induction by beta-lactams as well as by vancomycin is autoregulated. Induction of the pbp2 and vraSR operons by beta-lactams and related compounds within 1 hour after exposure to the antimicrobials was dependent on vraS. However, when a disk diffusion assay that can det ...[more]
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