Ontology highlight
ABSTRACT:
SUBMITTER: DeFilippis VR
PROVIDER: S-EPMC1346858 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Journal of virology 20060101 2
Viral infection activates interferon regulatory factor 3 (IRF3), a cofactor for the induction of interferon-stimulated genes (ISGs). The role of IRF3 in the activation of ISGs by human cytomegalovirus (HCMV) is controversial despite the fact that HCMV has consistently been shown to induce ISGs during infection of fibroblasts. To address the function of IRF3 in HCMV-mediated ISG induction, we monitored ISG expression and global gene expression in HCMV-infected cells in which IRF3 function had bee ...[more]