Ontology highlight
ABSTRACT:
SUBMITTER: Tchenio T
PROVIDER: S-EPMC1346900 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Tchénio Thierry T Havard Marilyne M Martinez Luis A LA Dautry François F
Molecular and cellular biology 20060101 2
The screening of two different retroviral cDNA expression libraries to select genes that confer constitutive doxorubicin resistance has in both cases resulted in the isolation of the heat shock factor 1 (HSF1) transcription factor. We show that HSF1 induces a multidrug resistance phenotype that occurs in the absence of heat shock or cellular stress and is mediated at least in part through the constitutive activation of the multidrug resistance gene 1 (MDR-1). This drug resistance phenotype does ...[more]