Ontology highlight
ABSTRACT:
SUBMITTER: Furusawa T
PROVIDER: S-EPMC1346905 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Furusawa Takashi T Lim Jae-Hwan JH Catez Frédéric F Birger Yehudit Y Mackem Susan S Bustin Michael M
Molecular and cellular biology 20060101 2
We find that during embryogenesis the expression of HMGN1, a nuclear protein that binds to nucleosomes and reduces the compaction of the chromatin fiber, is progressively down-regulated throughout the entire embryo, except in committed but continuously renewing cell types, such as the basal layer of the epithelium. In the developing limb bud, the expression of HMGN1 is complementary to Sox9, a master regulator of the chondrocyte lineage. In limb bud micromass cultures, which faithfully mimic in ...[more]