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ShiBASE: an integrated database for comparative genomics of Shigella.


ABSTRACT: Among the major enteric bacterial pathogens, Shigella is found to display extreme genome diversity and dynamics, which imposes a challenge in comparative genomic studies. To facilitate further studies in this area, we have constructed an integrated online database, ShiBASE (http://www.mgc.ac.cn/ShiBASE/),which contains Shigella genomic sequences of four species and additional comparative genomic hybridization (CGH) data of 43 serotypes. ShiBASE offers online comparative analysis on DNA sequences, gene orders, metabolic pathways and virulence factors. In addition, ShiBASE has a newly developed online comparative visualization service, Shi-align, which enables the alignment of any query sequence with the reference genome sequences.

SUBMITTER: Yang J 

PROVIDER: S-EPMC1347396 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature

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ShiBASE: an integrated database for comparative genomics of Shigella.

Yang Jian J   Chen Lihong L   Yu Jun J   Sun Lilian L   Jin Qi Q  

Nucleic acids research 20060101 Database issue


Among the major enteric bacterial pathogens, Shigella is found to display extreme genome diversity and dynamics, which imposes a challenge in comparative genomic studies. To facilitate further studies in this area, we have constructed an integrated online database, ShiBASE (http://www.mgc.ac.cn/ShiBASE/),which contains Shigella genomic sequences of four species and additional comparative genomic hybridization (CGH) data of 43 serotypes. ShiBASE offers online comparative analysis on DNA sequences  ...[more]

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