Plasmid-encoded autolysin in Bacillus anthracis: modular structure and catalytic properties.
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ABSTRACT:
SUBMITTER: Mesnage S
PROVIDER: S-EPMC134760 | biostudies-literature | 2002 Jan
REPOSITORIES: biostudies-literature
Publications
Plasmid-encoded autolysin in Bacillus anthracis: modular structure and catalytic properties.
Mesnage Stéphane S Fouet Agnès A
Journal of bacteriology 20020101 1
A Bacillus anthracis virulence plasmid-encoded peptidoglycan hydrolase (AmiA) with sequence similarity to N-acetylmuramoyl-L-alanine amidases hydrolyzes peptidoglycan independently of cell wall binding. Residues H341, E355, H415, and E486 are absolutely required for catalysis. Many AmiA paralogs are fused to different sorting signals, suggesting that these modular proteins result from domain shuffling. ...[more]
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