Ontology highlight
ABSTRACT:
SUBMITTER: Yoon SS
PROVIDER: S-EPMC1350997 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Yoon Sang Sun SS Coakley Ray R Lau Gee W GW Lymar Sergei V SV Gaston Benjamin B Karabulut Ahmet C AC Hennigan Robert F RF Hwang Sung-Hei SH Buettner Garry G Schurr Michael J MJ Mortensen Joel E JE Burns Jane L JL Speert David D Boucher Richard C RC Hassett Daniel J DJ
The Journal of clinical investigation 20060126 2
Mucoid, mucA mutant Pseudomonas aeruginosa cause chronic lung infections in cystic fibrosis (CF) patients and are refractory to phagocytosis and antibiotics. Here we show that mucoid bacteria perish during anaerobic exposure to 15 mM nitrite (NO2) at pH 6.5, which mimics CF airway mucus. Killing required a pH lower than 7, implicating formation of nitrous acid (HNO2) and NO, that adds NO equivalents to cellular molecules. Eighty-seven percent of CF isolates possessed mucA mutations and were kill ...[more]