Ontology highlight
ABSTRACT:
SUBMITTER: Ogasawara K
PROVIDER: S-EPMC1351289 | biostudies-literature | 2005 Sep
REPOSITORIES: biostudies-literature
Ogasawara Kouetsu K Benjamin Jonathan J Takaki Rayna R Phillips Joseph H JH Lanier Lewis L LL
Nature immunology 20050807 9
Irradiation-resistant natural killer (NK) cells in an F(1) recipient can reject parental bone marrow, and host NK cells can also prevent engraftment of allogeneic bone marrow. We show here that repopulating bone marrow cells in certain mouse strains expressed retinoic acid early inducible 1 proteins, which are ligands for the activating NKG2D NK cell receptor. Treatment with a neutralizing antibody to NKG2D prevented rejection of parental BALB/c bone marrow in (C57BL/6 x BALB/c) F(1) recipients ...[more]