Ontology highlight
ABSTRACT:
SUBMITTER: Matsuoka T
PROVIDER: S-EPMC1352163 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
Matsuoka Toshiyuki T Ahlberg Per E PE Kessaris Nicoletta N Iannarelli Palma P Dennehy Ulla U Richardson William D WD McMahon Andrew P AP Koentges Georgy G
Nature 20050701 7049
The neck and shoulder region of vertebrates has undergone a complex evolutionary history. To identify its underlying mechanisms we map the destinations of embryonic neural crest and mesodermal stem cells using Cre-recombinase-mediated transgenesis. The single-cell resolution of this genetic labelling reveals cryptic cell boundaries traversing the seemingly homogeneous skeleton of the neck and shoulders. Within this assembly of bones and muscles we discern a precise code of connectivity that mese ...[more]